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Showing 1–14 of 14 results
Advanced filters: Author: Zhixun Dou Clear advanced filters

  • Single-cell proteomics (SCP) enables detailed protein profiling at the individual cell level but is highly sensitive to sample preparation artifact. Here, the authors address protein leakage artifacts in single-cell proteomics and define a leakage signature, revealing higher leakage in cytosolic/nuclear proteins.

    • Andrew Leduc
    • Yanxin Xu
    • Nikolai Slavov
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-6

  • During chronic but not acute inflammation, chromatin remodelling is influenced by nuclear autophagy through WSTF interaction with ATG8 in the nucleus, leading to WSTF nuclear export and its subsequent degradation.

    • Yu Wang
    • Vinay V. Eapen
    • Zhixun Dou
    Research
    Nature
    Volume: 644, P: 780-789

  • During senescence, minority mitochondrial outer membrane permeabilization leads to the release of mtDNA into the cytosol through BAX and BAK macropores, in turn activating the cGAS–STING pathway, a major regulator of the senescence-associated secretory phenotype.

    • Stella Victorelli
    • Hanna Salmonowicz
    • João F. Passos
    ResearchOpen Access
    Nature
    Volume: 622, P: 627-636

  • Apolipoprotein E (APOE) is an important regulator of lipid metabolism and is genetically associated with longevity and age-related diseases such as Alzheimer’s disease. However, the molecular mechanisms that link APOE and aging are incompletely understood. Now an article in Nature Aging reveals that nuclear APOE promotes senescence by destabilizing heterochromatin.

    • Lu Wang
    • Zhixun Dou
    News & Views
    Nature Aging
    Volume: 2, P: 282-284

  • A ChIP-seq analysis of the DNA-binding properties of mutant gain-of-function p53 protein compared to wild-type p53 reveals the gain-of-function proteins bind to and activate a distinct set of genes including chromatin modifying enzymes such as the histone methyltransferase MLL; small molecular inhibitors of MLL function may represent a new target for cancers with mutant p53.

    • Jiajun Zhu
    • Morgan A. Sammons
    • Shelley L. Berger
    Research
    Nature
    Volume: 525, P: 206-211

  • Xu et al. report that nuclear SIRT1 is recognized as an autophagy substrate during senescence and also observe ageing of the immune system.

    • Caiyue Xu
    • Lu Wang
    • Shelley L. Berger
    Research
    Nature Cell Biology
    Volume: 22, P: 1170-1179

  • Senescent cells have complex and important roles in cancer and ageing, but they are quite rare and difficult to characterize in tissues in vivo. In this Expert Recommendation, the SenNet Biomarkers Working Group discusses recent advances in detecting and characterizing cellular senescence and provides recommendations for senescence markers in 14 human and mouse tissues.

    • Vidyani Suryadevara
    • Adam D. Hudgins
    • Nicola Neretti
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 25, P: 1001-1023

  • In response to cancer-associated stress, autophagy machinery mediates degradation of nuclear lamina components in mammals, suggesting that cells might degrade nuclear components to prevent tumorigenesis.

    • Zhixun Dou
    • Caiyue Xu
    • Shelley L. Berger
    Research
    Nature
    Volume: 527, P: 105-109

  • Cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS–STING pathway, leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation that associates with tissue destruction and cancer.

    • Zhixun Dou
    • Kanad Ghosh
    • Shelley L. Berger
    Research
    Nature
    Volume: 550, P: 402-406