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Tcf1 and Lef1 transcription factors establish CD8⁺ T cell identity through intrinsic HDAC activity

Xue and colleagues show that the transcription factors Tcf1 and Lef1 suppress CD4⁺ T lineage genes in CD8⁺ T cells through intrinsic histone deacetylase (HDAC) activity.

Shaojun Xing
Fengyin Li
Hai-Hui Xue
Research25 Apr 2016
Nature Immunology

Volume: 17, P: 695-703
The transcription factor Runx3 guards cytotoxic CD8⁺ effector T cells against deviation towards follicular helper T cell lineage

Xue and colleagues show that Runx3^−/− CD8⁺ T effector cells aberrantly upregulate genes characteristic of T_FH cell lineage and exhibit impaired induction of cytotoxic molecules.

Qiang Shan
Zhouhao Zeng
Hai-Hui Xue
Research12 Jun 2017
Nature Immunology

Volume: 18, P: 931-939
Tcf1 and Lef1 provide constant supervision to mature CD8⁺ T cell identity and function by organizing genomic architecture

How CD8⁺ T cell identity is maintained after exit from the thymus is not fully established. Here the authors use multiomics approaches including Hi-C to show that Tcf1 and Lef1 prevent aberrant expression of lineage-inappropriate genes by organizing three-dimensional genomic architecture in CD8⁺ T cells.

Qiang Shan
Xiang Li
Hai-Hui Xue
ResearchOpen Access06 Oct 2021
Nature Communications

Volume: 12, P: 1-20
Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features

CTCF mediates long-range chromatin interactions which are important for genome organization and function. Here, the authors demonstrate that CTCF-mediated interactome exhibits extensive plasticity and present Lollipop, a machine-learning framework which predicts CTCF-mediated long-range interactions using genomic and epigenomic features.

Yan Kai
Jaclyn Andricovich
Weiqun Peng
ResearchOpen Access11 Oct 2018
Nature Communications

Volume: 9, P: 1-14
Ezh2 programs T_FH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf

Ezh2 is an histone methyltransferase that catalyzes H3K27me3. Here the authors show that Ezh2 promotes T follicular helper (T_FH) differentiation and helper activity, by cooperating with Tcf1 to activate Bcl6 transcription and epigenetically repressing p19Arf, an antagonist of Bcl6 function and T_FH cell survival.

Fengyin Li
Zhouhao Zeng
Hai-Hui Xue
ResearchOpen Access21 Dec 2018
Nature Communications

Volume: 9, P: 1-18
LEF-1 and TCF-1 orchestrate T_FH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6

Follicular helper T cells (T_FH cells) are specialized effector CD4⁺ T cells that help B cells develop germinal centers and memory. Crotty and colleagues show that the transcription factors LEF-1 and TCF-1 are required for early T_FH differentiation.

Youn Soo Choi
Jodi A Gullicksrud
Shane Crotty
Research27 Jul 2015
Nature Immunology

Volume: 16, P: 980-990
Abnormalities in intron retention characterize patients with systemic lupus erythematosus

Xiaoqian Sun
Zhichao Liu
Peter E. Lipsky
ResearchOpen Access29 Mar 2023
Scientific Reports

Volume: 13, P: 1-10

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Tcf1 and Lef1 transcription factors establish CD8+ T cell identity through intrinsic HDAC activity

The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage

Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture

Predicting CTCF-mediated chromatin interactions by integrating genomic and epigenomic features

Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf

LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6

Abnormalities in intron retention characterize patients with systemic lupus erythematosus

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Tcf1 and Lef1 transcription factors establish CD8⁺ T cell identity through intrinsic HDAC activity

The transcription factor Runx3 guards cytotoxic CD8⁺ effector T cells against deviation towards follicular helper T cell lineage

Tcf1 and Lef1 provide constant supervision to mature CD8⁺ T cell identity and function by organizing genomic architecture

Ezh2 programs T_FH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf

LEF-1 and TCF-1 orchestrate T_FH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6