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Showing 1–8 of 8 results
Advanced filters: Author: Zhuoya Dong Clear advanced filters

  • Quantifying enantiomorphs in crystalline powders remains challenging. Now, a combination of serial three-dimensional electron diffraction and dynamical simulations has enabled the high-throughput determination of the absolute structure and enantiomorphic excess in chiral crystalline powders and can be applied to both inorganic and organic materials.

    • Junyi Hu
    • Zhuoya Dong
    • Yanhang Ma
    Research
    Nature Chemistry
    P: 1-7

  • Hyperuricemia, a major cause of gout, results from impaired urate excretion. Here, the authors reveal how key anti-gout drugs block URAT1, providing structural insights for designing better hyperuricemia treatments.

    • Zhuoya Yu
    • Tuo Hu
    • Yan Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Handedness or chirality determination of crystals has always been challenging for chemists, biologists and materials scientists. Here, the authors report a method for handedness determination by atomic-resolution imaging using Cs-corrected scanning transmission electron microscopy.

    • Zhuoya Dong
    • Yanhang Ma
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-6

  • CaV1.2 is crucial in cardiac, vascular and neuronal function, serving as a target for many drugs. Here, authors identify the binding site of herb-derived drug tetrandrine, and explore inhibitory mechanism of L/T-type selective DHP drug benidipine.

    • Yiqing Wei
    • Zhuoya Yu
    • Yan Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • T-type calcium channels are implicated in many diseases. Here, multiple structures of CaV3.3 channel elucidate molecular mechanisms of T-type CaV channels activation at low voltage and interaction with different clinically used channel blockers.

    • Lingli He
    • Zhuoya Yu
    • Yan Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • Excitatory amino acid transporter 2 (EAAT2) mediates glutamate uptake in the synapse. Here, authors report cryo-EM structures of the human EAAT2 in complexes with glutamate or selective inhibitor WAY-213613, revealing important insights into substrate recognition and selective inhibition.

    • Zhenglai Zhang
    • Huiwen Chen
    • Yan Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • The ability to control defects offers the opportunity to design porous materials with desired properties. Here the authors present a strategy to control the generation and growth of periodic missing cluster vacancies in UiO-66 frameworks and analyze their impact on the physical properties and catalytic activity.

    • Sergio Tatay
    • Sonia Martínez-Giménez
    • Carlos Martí-Gastaldo
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12