Nature Search

Redox regulation of m⁶A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes

De Jesus et al. describe the redox-mediated regulation of m⁶A writer methyltransferase 3, which blunts innate immune responses by modification of RNA sensor and editor component mRNAs during the onset of type 1 diabetes in β-cells.

Dario F. De Jesus
Zijie Zhang
Rohit N. Kulkarni
Research26 Feb 2024
Nature Cell Biology

Volume: 26, P: 421-437
π-PrimeNovo: an accurate and efficient non-autoregressive deep learning model for de novo peptide sequencing

Peptide sequencing is critical to the advancement of proteomics research. Here, the authors present π-PrimeNovo, a non-autoregressive deep learning model that achieves high accuracy and up to 89x faster sequencing. This enables large-scale sequencing and multiple downstream applications.

Xiang Zhang
Tianze Ling
Siqi Sun
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-16
RNA m⁵C oxidation by TET2 regulates chromatin state and leukaemogenesis

Chromatin-associated retrotransposon RNA 5-methylcytosine can be recognized by the methyl-CpG-binding-domain protein MBD6, which guides deubiquitination of nearby monoubiquitinated Lys119 of histone H2A to promote an open chromatin state in TET2-deficient cells.

Zhongyu Zou
Xiaoyang Dou
Chuan He
ResearchOpen Access02 Oct 2024
Nature

Volume: 634, P: 986-994
Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis

Here, the authors show how Aurora kinase A (AURKA) employs Rab1a to direct ER remodeling. Activated Rab1A is retained on the ER and directly interacts with the RTN/REEP ER-shaping machinery to promote its oligomerization, eventually triggering an increase of ER complexity during mitosis.

Wei Zhang
Zijian Zhang
Quentin Liu
Research04 Jan 2024
Nature Structural & Molecular Biology

Volume: 31, P: 219-231
N⁶-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I

This study reports a novel function for the N⁶-methyladenosine RNA modification in allowing RIG-I to discriminate self from non-self RNA and shows that human metapneumovirus induces this modification of its RNA to evade recognition in vivo.

Mijia Lu
Zijie Zhang
Jianrong Li
Research03 Feb 2020
Nature Microbiology

Volume: 5, P: 584-598
Genetic analyses support the contribution of mRNA N⁶-methyladenosine (m⁶A) modification to human disease heritability

Quantitative trait locus (QTL) mapping of N⁶-methyladenosine (m⁶A) in human cells highlights the role of RNA-binding proteins, RNA secondary structure and context-dependent m⁶A effects. m⁶A QTLs are enriched in loci associated with immune and blood-related traits.

Zijie Zhang
Kaixuan Luo
Chuan He
Research29 Jun 2020
Nature Genetics

Volume: 52, P: 939-949
Reconstitution of the lipid-linked oligosaccharide pathway for assembly of high-mannose N-glycans

Attachment of the oligosaccharide Man9GlcNAc2 is required for glycoprotein folding and secretion but synthesizing this compound for structural and functional studies has remained challenging. Here, the authors achieve efficient Man9GlcNAc2 synthesis by reconstituting its biosynthetic pathway in vitro.

Sheng-Tao Li
Tian-Tian Lu
Xiao-Dong Gao
ResearchOpen Access18 Apr 2019
Nature Communications

Volume: 10, P: 1-11
Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphoma

A recurrent ECSIT mutation in individuals with extranodal natural killer/T cell lymphoma induces NFκB in cancer cells, leading to macrophage activation, and associates with progression to fatal hemophagocytic syndrome. NFκB-targeting therapy produced stable remission in two patients.

Haijun Wen
Huajuan Ma
Quentin Liu
Research01 Jan 2018
Nature Medicine

Volume: 24, P: 154-164
Suprabasin promotes gastric cancer liver metastasis via hepatic stellate cells-mediated EGF/CCL2/JAK2 intercellular signaling pathways

Difeng Li
Zhiqing Gao
Lili Jiang
Research03 Apr 2025
Oncogene

Volume: 44, P: 1975-1989
Differences in rectal amino acid levels determine bacteria-originated sex pheromone specificity in two closely related flies

Zijie Gao
Mingxue Xie
Daifeng Cheng
ResearchOpen Access07 Aug 2023
The ISME Journal

Volume: 17, P: 1741-1750
Identification of PLOD3 and LRRN3 as potential biomarkers for Parkinson’s disease based on integrative analysis

Xing Guo
Wenjun Hu
Weiguo Li
ResearchOpen Access31 May 2023
npj Parkinson's Disease

Volume: 9, P: 1-10
Rare sugar l-sorbose exerts antitumor activity by impairing glucose metabolism

The rare sugar L-sorbose is shown to decrease cell viability and increase apoptotic cells in culture and to enhance the effect of tumor chemotherapy in combination with sorafenib in mouse xenograft models.

Hui-Lin Xu
Xiaoman Zhou
Xiao-Dong Gao
ResearchOpen Access11 Mar 2023
Communications Biology

Volume: 6, P: 1-17
A low-voltage-driven MEMS ultrasonic phased-array transducer for fast 3D volumetric imaging

Yun Zhang
Tong Jin
Hang Gao
ResearchOpen Access12 Sept 2024
Microsystems & Nanoengineering

Volume: 10, P: 1-16
Hypoxic glioma-derived exosomes promote M2-like macrophage polarization by enhancing autophagy induction

Jianye Xu
Jian Zhang
Gang Li
ResearchOpen Access07 Apr 2021
Cell Death & Disease

Volume: 12, P: 1-16
Glioblastoma upregulates SUMOylation of hnRNP A2/B1 to eliminate the tumor suppressor miR-204-3p, accelerating angiogenesis under hypoxia

Qindong Guo
Yang Fan
Gang Li
ResearchOpen Access21 Feb 2023
Cell Death & Disease

Volume: 14, P: 1-14
Hypoxia-induced circADAMTS6 in a TDP43-dependent manner accelerates glioblastoma progression via ANXA2/ NF-κB pathway

Shulin Zhao
Boyan Li
Gang Li
Research17 Nov 2022
Oncogene

Volume: 42, P: 138-153
Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1

Heng Xu
Hongfang Zhao
Hao Zhang
ResearchOpen Access03 Feb 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-16
Tumor-derived exosomes deliver the tumor suppressor miR-3591-3p to induce M2 macrophage polarization and promote glioma progression

Ming Li
Hao Xu
Gang Li
ResearchOpen Access09 Sept 2022
Oncogene

Volume: 41, P: 4618-4632
The dual role of glioma exosomal microRNAs: glioma eliminates tumor suppressor miR-1298-5p via exosomes to promote immunosuppressive effects of MDSCs

Yanhua Qi
Chuandi Jin
Gang Li
ResearchOpen Access02 May 2022
Cell Death & Disease

Volume: 13, P: 1-15
Global immune characterization of HBV/HCV-related hepatocellular carcinoma identifies macrophage and T-cell subsets associated with disease progression

Guohe Song
Yang Shi
Qiang Gao
ResearchOpen Access08 Dec 2020
Cell Discovery

Volume: 6, P: 1-15
Origin identification of Chinese Maca using electronic nose coupled with GC-MS

Aimin Li
Shenglin Duan
Xiao-Dong Gao
ResearchOpen Access21 Aug 2019
Scientific Reports

Volume: 9, P: 1-10

Search

Redox regulation of m⁶A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes

π-PrimeNovo: an accurate and efficient non-autoregressive deep learning model for de novo peptide sequencing

RNA m⁵C oxidation by TET2 regulates chromatin state and leukaemogenesis

Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis

N⁶-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I

Genetic analyses support the contribution of mRNA N⁶-methyladenosine (m⁶A) modification to human disease heritability

Reconstitution of the lipid-linked oligosaccharide pathway for assembly of high-mannose N-glycans

Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphoma

Suprabasin promotes gastric cancer liver metastasis via hepatic stellate cells-mediated EGF/CCL2/JAK2 intercellular signaling pathways

Differences in rectal amino acid levels determine bacteria-originated sex pheromone specificity in two closely related flies

Identification of PLOD3 and LRRN3 as potential biomarkers for Parkinson’s disease based on integrative analysis

Rare sugar l-sorbose exerts antitumor activity by impairing glucose metabolism

A low-voltage-driven MEMS ultrasonic phased-array transducer for fast 3D volumetric imaging

Hypoxic glioma-derived exosomes promote M2-like macrophage polarization by enhancing autophagy induction

Glioblastoma upregulates SUMOylation of hnRNP A2/B1 to eliminate the tumor suppressor miR-204-3p, accelerating angiogenesis under hypoxia

Hypoxia-induced circADAMTS6 in a TDP43-dependent manner accelerates glioblastoma progression via ANXA2/ NF-κB pathway

Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1

Tumor-derived exosomes deliver the tumor suppressor miR-3591-3p to induce M2 macrophage polarization and promote glioma progression

The dual role of glioma exosomal microRNAs: glioma eliminates tumor suppressor miR-1298-5p via exosomes to promote immunosuppressive effects of MDSCs

Global immune characterization of HBV/HCV-related hepatocellular carcinoma identifies macrophage and T-cell subsets associated with disease progression

Origin identification of Chinese Maca using electronic nose coupled with GC-MS

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