Nature Search

Metabolomics and proteomics reveal blocking argininosuccinate synthetase 1 alleviates colitis in mice

The management of ulcerative colitis (UC) remains challenging due to the complexity of its etiology. Here, the authors establish that argininosuccinate synthetase 1 (ASS1) and its metabolite arginine are pivotal inducers of UC, through the triggering of mTOR and iNOS activation, and the induction of gut microbiota dysbiosis by metabolomics and proteomics. Inhibition of ASS1 by C-01 provides a viable strategy for the treatment of UC.

Shijia Liu
Haijian Sun
Wei Zhou
ResearchOpen Access30 Jul 2025
Nature Communications

Volume: 16, P: 1-22
The Deinococcus protease PprI senses DNA damage by directly interacting with single-stranded DNA

Lu et al. show that single-stranded DNA produced as a result of DNA damage may directly activate PprI in Deinococcus species, triggering the DNA damage response.

Huizhi Lu
Zijing Chen
Yuejin Hua
ResearchOpen Access29 Feb 2024
Nature Communications

Volume: 15, P: 1-13
Single-nucleus and spatial transcriptomics identify brain landscape of gene regulatory networks associated with behavioral maturation in honeybees

Honeybee behavioral plasticity provides a model to study how brain gene networks regulate behavior. Here, authors show stripe activation in Kenyon cells links gene regulatory networks to behavioral maturation via spatial-cellular coordination.

Xiaohuan Mu
Zijing Zhang
Hao Zheng
ResearchOpen Access08 Apr 2025
Nature Communications

Volume: 16, P: 1-16
Origin of the multi-phasic quenching dynamics in the BLUF domains across the species

Here the authors combine 19 F NMR and femtosecond transient absorption to characterise the structural origin of the multiphasic quenching dynamics in various species of BLUF domains, highlighting the importance of the heterogeneous active-site H-bond network.

Yalin Zhou
Siwei Tang
Dongping Zhong
ResearchOpen Access20 Jan 2024
Nature Communications

Volume: 15, P: 1-11
Mapping the role of cytokine signaling at single-cell and structural resolution in uveal melanoma

Hongzhan Lin
Zixia Zhou
Ming-ming Yang
Research09 Jun 2025
Genes & Immunity

Volume: 26, P: 324-341
Associations between corneal curvature and other anterior segment biometrics in young myopic adults

Li Jiang
Zijing Du
Yijun Hu
ResearchOpen Access09 Apr 2024
Scientific Reports

Volume: 14, P: 1-7
Ocular biometrics in eyes with different white-to-white corneal diameter in young myopic adults

Li Jiang
Zijing Du
Yijun Hu
ResearchOpen Access27 Feb 2024
Scientific Reports

Volume: 14, P: 1-7
Transient dynamics of the phase transition in VO₂ revealed by mega-electron-volt ultrafast electron diffraction

The atomic pathway in the photoinduced ultrafast structural phase transition of VO₂ has been a controversial problem for a long time. Here the authors, using MeV ultrafast electron diffraction, show that the melting of V-V dimers and the transformation of crystal symmetry are two processes with different timescales.

Chenhang Xu
Cheng Jin
Dong Qian
ResearchOpen Access07 Mar 2023
Nature Communications

Volume: 14, P: 1-8
Fat mass in postmenopausal women with osteoporosis is associated with cognitive function

Dongxue Zhang
Zijing Zhu
Yongli Wang
ResearchOpen Access24 May 2025
Scientific Reports

Volume: 15, P: 1-10
Oscillating edge states in one-dimensional MoS₂ nanowires

Unusual properties arise in transition metal dichalcogenides as dimensionality decreases. Here, the authors introduce a templated growth approach to precisely control the width of MoS₂nanowires on a substrate, allowing them to reveal a relationship between size and electronic properties.

Hai Xu
Shuanglong Liu
Kian Ping Loh
ResearchOpen Access04 Oct 2016
Nature Communications

Volume: 7, P: 1-8
Two-dimensional tessellation by molecular tiles constructed from halogen–halogen and halogen–metal networks

Molecular tessellations of complex tilings are difficult to design and construct. Here, the authors show that molecular tessellations can be formed from a single building block that gives rise to two distinct supramolecular phases, whose self-similar subdomains serve as tiles in the periodic tessellations.

Fang Cheng
Xue-Jun Wu
Kian Ping Loh
ResearchOpen Access19 Nov 2018
Nature Communications

Volume: 9, P: 1-8
Machine learning-based model for CD4⁺ conventional T cell genes to predict survival and immune responses in colorectal cancer

Zijing Wang
Zhanyuan Sun
Tao Jiang
ResearchOpen Access18 Oct 2024
Scientific Reports

Volume: 14, P: 1-15
Thin-film actuators (TFAs): a review

Zijing Zhang
Zhihua Liang
Haimin Yao
ReviewsOpen Access01 Aug 2025
npj Robotics

Volume: 3, P: 1-18
Identification of differentially expressed tumour-related genes regulated by UHRF1-driven DNA methylation

Qincai Dong
Chunxue Gong
Xuan Liu
ResearchOpen Access07 Aug 2024
Scientific Reports

Volume: 14, P: 1-14
A gamepad-like nucleic acid testing device for rapid detection of SARS-CoV-2 via visible nested recombinase polymerase amplification

Ce Liu, Baobao Lin and colleagues report a rapid and straightforward nucleic acid screening test requiring no professional training or formal medical setting. The device runs on a novel gamepad-like interface and fully integrates nucleic acid release, amplification, and visualization.

Ce Liu
Baobao Lin
Jingwei Bai
ResearchOpen Access21 Jun 2024
Communications Engineering

Volume: 3, P: 1-11
Implementation of the visual aesthetic quality of slope forest autumn color change into the configuration of tree species

Yanxia Mu
Wenyue Lin
Changyou Zhao
ResearchOpen Access20 Jan 2022
Scientific Reports

Volume: 12, P: 1-19
Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation

Ting Gao
Lin Zhu
Cheng Cao
ResearchOpen Access14 Sept 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-15
Macrophage polarization in experimental and clinical choroidal neovascularization

Yu Yang
Fang Liu
Lin Lu
ResearchOpen Access04 Aug 2016
Scientific Reports

Volume: 6, P: 1-12
Plasmonic–perovskite solar cells, light emitters, and sensors

Bin Ai
Ziwei Fan
Zi Jing Wong
ReviewsOpen Access12 Jan 2022
Microsystems & Nanoengineering

Volume: 8, P: 1-28

Search

Metabolomics and proteomics reveal blocking argininosuccinate synthetase 1 alleviates colitis in mice

The Deinococcus protease PprI senses DNA damage by directly interacting with single-stranded DNA

Single-nucleus and spatial transcriptomics identify brain landscape of gene regulatory networks associated with behavioral maturation in honeybees

Origin of the multi-phasic quenching dynamics in the BLUF domains across the species

Mapping the role of cytokine signaling at single-cell and structural resolution in uveal melanoma

Associations between corneal curvature and other anterior segment biometrics in young myopic adults

Ocular biometrics in eyes with different white-to-white corneal diameter in young myopic adults

Transient dynamics of the phase transition in VO₂ revealed by mega-electron-volt ultrafast electron diffraction

Fat mass in postmenopausal women with osteoporosis is associated with cognitive function

Oscillating edge states in one-dimensional MoS₂ nanowires

Two-dimensional tessellation by molecular tiles constructed from halogen–halogen and halogen–metal networks

Machine learning-based model for CD4⁺ conventional T cell genes to predict survival and immune responses in colorectal cancer

Thin-film actuators (TFAs): a review

Identification of differentially expressed tumour-related genes regulated by UHRF1-driven DNA methylation

A gamepad-like nucleic acid testing device for rapid detection of SARS-CoV-2 via visible nested recombinase polymerase amplification

Implementation of the visual aesthetic quality of slope forest autumn color change into the configuration of tree species

Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation

Macrophage polarization in experimental and clinical choroidal neovascularization

Plasmonic–perovskite solar cells, light emitters, and sensors

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