Nature Search

Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Mapping cells through time and space with moscot

Moscot is an optimal transport approach that overcomes current limitations of similar methods to enable multimodal, scalable and consistent single-cell analyses of datasets across spatial and temporal dimensions.

Dominik Klein
Giovanni Palla
Fabian J. Theis
ResearchOpen Access22 Jan 2025
Nature

Volume: 638, P: 1065-1075
Directly imaging spin polarons in a kinetically frustrated Hubbard system

A triangular-lattice Hubbard system realized with ultracold atoms is used to directly image spin polarons, revealing ferromagnetic correlations around a charge dopant, a manifestation of the Nagaoka effect.

Max L. Prichard
Benjamin M. Spar
Waseem S. Bakr
Research08 May 2024
Nature

Volume: 629, P: 323-328
Collective flow of fermionic impurities immersed in a Bose–Einstein condensate

The complex interactions arising in mixtures of bosons and fermions make it hard to understand their coupled dynamics. The collective oscillations of fermions embedded in a boson condensate have now been characterized in an ultracold-atom experiment.

Zoe Z. Yan
Yiqi Ni
Martin Zwierlein
Research21 Jun 2024
Nature Physics

Volume: 20, P: 1395-1400
Biomimetic cell stimulation with a graphene oxide antigen-presenting platform for developing T cell-based therapies

Current CAR T cell manufacturing falls short of mimicking immunological synapses. A new graphene oxide antigen-presenting platform (GO-APP) addresses this issue, improving CAR T cell production while eliminating the need for interleukin-2 supplementation.

Enbo Zhu
Jiaji Yu
Yu Huang
Research23 Sept 2024
Nature Nanotechnology

Volume: 19, P: 1914-1922
Probing site-resolved correlations in a spin system of ultracold molecules

Experiments demonstrate the powerful capabilities of ultracold molecules to study dynamics in the context of quantum magnetism, and create new possibilities for studying quantum physics with ultracold molecules more broadly.

Lysander Christakis
Jason S. Rosenberg
Waseem S. Bakr
Research01 Feb 2023
Nature

Volume: 614, P: 64-69
Generation of allogeneic CAR-NKT cells from hematopoietic stem and progenitor cells using a clinically guided culture method

Off-the-shelf CAR-NKT cells for cancer immunotherapy are advanced toward clinical translation.

Yan-Ruide Li
Yang Zhou
Lili Yang
ResearchOpen Access14 May 2024
Nature Biotechnology

Volume: 43, P: 329-344
Observation of the Hanbury Brown–Twiss effect with ultracold molecules

The study of statistical correlations is central to the description of complex quantum objects. Measurements of density correlation functions of ultracold molecules are now possible through the realization of a molecular quantum gas microscope.

Jason S. Rosenberg
Lysander Christakis
Waseem S. Bakr
Research11 Aug 2022
Nature Physics

Volume: 18, P: 1062-1066
The origin of suspended particulate matter in the Great Barrier Reef

This multidisciplinary fingerprinting study, using isotopic, structural and genetic fingerprints, has shown that the suspended particulate matter in the Great Barrier Reef does not have terrestrial origin but produced locally by marine phytoplankton

Mohammad Bahadori
Chengrong Chen
Tom Stevens
ResearchOpen Access12 Sept 2023
Nature Communications

Volume: 14, P: 1-11
The Reliever Reliance Test: evaluating a new tool to address SABA over-reliance

Zoe Moon
Alan Kaplan
Rob Horne
ResearchOpen Access05 Nov 2024
npj Primary Care Respiratory Medicine

Volume: 34, P: 1-7
Lung adenocarcinoma promotion by air pollutants

Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer

William Hill
Emilia L. Lim
Charles Swanton
Research05 Apr 2023
Nature

Volume: 616, P: 159-167
Copy number architectures define treatment-mediated selection of lethal prostate cancer clones

The heterogeneity of androgen receptor (AR) gene alterations across metastases in prostate cancer remains unresolved. Here, the authors characterise AR genomic complexity across spatially separated lethal metastases from 10 prostate cancer patients and investigate how AR alterations evolve.

A. M. Mahedi Hasan
Paolo Cremaschi
Gerhardt Attard
ResearchOpen Access10 Aug 2023
Nature Communications

Volume: 14, P: 1-16
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice

In Alzheimer’s disease, neurons are considered the sole source of amyloid-β (Aβ) peptides that form plaques. Here the authors show that oligodendrocytes, the myelinating glial cells of the brain, also contribute to Aβ plaque burden alongside neurons.

Andrew Octavian Sasmita
Constanze Depp
Klaus-Armin Nave
ResearchOpen Access05 Aug 2024
Nature Neuroscience

Volume: 27, P: 1668-1674
Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

Alzheimer disease (AD) and related dementias share numerous mechanistic and epidemiological similarities with type 2 diabetes mellitus (T2DM). However, whether these associations result from synergistic interactions between the disorders is unclear. This Review summarizes our current knowledge regarding insulin signalling and resistance in the brain and discusses current evidence concerning neurological impairment in T2DM and insulin resistance in AD.

Steven E. Arnold
Zoe Arvanitakis
David M. Nathan
Reviews29 Jan 2018
Nature Reviews Neurology

Volume: 14, P: 168-181
Reporting the epidemiology of aural haematoma in dogs and proposing a novel aetiopathogenetic pathway

Dan G. O’Neill
Yan Hui Lee
Zoë Halfacree
ResearchOpen Access09 Nov 2021
Scientific Reports

Volume: 11, P: 1-13
A second cohort of CHD3 patients expands the molecular mechanisms known to cause Snijders Blok-Campeau syndrome

Theodore G. Drivas
Dong Li
Elizabeth Bhoj
Research01 Jun 2020
European Journal of Human Genetics

Volume: 28, P: 1422-1431
Radiofrequency therapy improves exercise capacity of mice with emphysema

Mai Tsutsui
Chung Yan Cheung
Don D. Sin
ResearchOpen Access08 Oct 2021
Scientific Reports

Volume: 11, P: 1-10

Search

Whole-genome sequencing reveals host factors underlying critical COVID-19

Mapping the human genetic architecture of COVID-19

Mapping cells through time and space with moscot

Directly imaging spin polarons in a kinetically frustrated Hubbard system

Collective flow of fermionic impurities immersed in a Bose–Einstein condensate

Biomimetic cell stimulation with a graphene oxide antigen-presenting platform for developing T cell-based therapies

Probing site-resolved correlations in a spin system of ultracold molecules

Generation of allogeneic CAR-NKT cells from hematopoietic stem and progenitor cells using a clinically guided culture method

Observation of the Hanbury Brown–Twiss effect with ultracold molecules

The origin of suspended particulate matter in the Great Barrier Reef

The Reliever Reliance Test: evaluating a new tool to address SABA over-reliance

Lung adenocarcinoma promotion by air pollutants

Copy number architectures define treatment-mediated selection of lethal prostate cancer clones

Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

Reporting the epidemiology of aural haematoma in dogs and proposing a novel aetiopathogenetic pathway

A second cohort of CHD3 patients expands the molecular mechanisms known to cause Snijders Blok-Campeau syndrome

Radiofrequency therapy improves exercise capacity of mice with emphysema

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