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Showing 1–2 of 2 results
Advanced filters: Author: Zoya Qureshy Clear advanced filters

  • Age-related macular degeneration is characterized by lipid-rich drusen deposits underneath the retinal pigment epithelium (RPE). Here the authors report an in vitro iPSC-RPE model for AMD that recapitulates drusen and RPE atrophy, and identify two drugs that reduce drusen deposits and restore RPE epithelial phenotype.

    • Ruchi Sharma
    • Aman George
    • Kapil Bharti
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Miyagishima et al. investigate the pathological mechanisms underlying mutant CTRP5 function in late-onset retinal degeneration (L-ORD). With human iPSC-derived RPE cells, they demonstrate that in L-ORD iRPE, constitutive activation of AMPK disrupts cellular metabolism/energy homoeostasis, changes apical/basal VEGF secretion, and Metformin treatment corrects these associated phenotypes.

    • Kiyoharu J. Miyagishima
    • Ruchi Sharma
    • Kapil Bharti
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-16