Basolateral polarity articles from across Nature Portfolio

Latest Research and Reviews

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  Structural basis of human VANGL-PRICKLE interaction

  The authors present cryo-electron structures of human VANGL1, VANGL2 and their complexes with PK1, unveiling the molecular underpinnings of the VANGL-PK interaction and paving the way for future investigations into the planar cell polarity pathway

  • Yanyi Song
  • Shuyi Jian
  • Zhe Zhang

  ResearchOpen Access03 Jan 2025 Nature Communications

  Volume: 16, P: 132
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  Dynamic interactions between E-cadherin and Ankyrin-G mediate epithelial cell polarity maintenance

  The maintenance of cell polarity depends on adhesion complexes that tether to the cytoskeleton. Here the authors show the dynamic nature of E-cadherin–Ankyrin-G complex formation and investigate its functional role in epithelial cell polarity maintenance.

  • Chao Kong
  • Xiaozhan Qu
  • Chao Wang

  ResearchOpen Access27 Oct 2023 Nature Communications

  Volume: 14, P: 6860
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  Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury

  A common cellular manifestation for diverse kidney diseases is dysregulated actin cytoskeleton in distinct cell types that include glomerular podocytes and tubular epithelial cells. Here, authors pharmacologically activate dynamin and this results in polymerization and crosslinking of actin filaments to establish the structural integrity of these cells, thus ameliorating disease phenotypes.

  • Kamalika Mukherjee
  • Changkyu Gu
  • Sanja Sever

  ResearchOpen Access03 May 2022 Nature Communications

  Volume: 13, P: 2422
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  Polarity protein SCRIB interacts with SLC3A2 to regulate proliferation and tamoxifen resistance in ER+ breast cancer

  A complex involving polarity protein SCRIB and the leucine amino acid transporter SLC7A5 promotes cell proliferation and tamoxifen resistance in estrogen receptor-positive breast cancer cells.

  • Yasuhiro Saito
  • Shiori Matsuda
  • Senthil K. Muthuswamy

  ResearchOpen Access02 May 2022 Communications Biology

  Volume: 5, P: 403
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  Decrease of Pdzrn3 is required for heart maturation and protects against heart failure

  • Mathieu Pernot
  • Béatrice Jaspard-vinassa
  • Cécile Duplàa

  ResearchOpen Access07 Jan 2022 Scientific Reports

  Volume: 12, P: 8
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  Mouse embryo geometry drives formation of robust signaling gradients through receptor localization

  How receptor localization affects morphogen gradient formation during embryonic development is unclear. Here, the authors study the relationship between the BMP gradient, receptor localization, and compartmentalized geometry in the early mouse embryo, using experimental data and computational simulation.

  • Zhechun Zhang
  • Steven Zwick
  • Sharad Ramanathan

  ResearchOpen Access04 Oct 2019 Nature Communications

  Volume: 10, P: 4516