Biotechnology articles from across Nature Portfolio

We show that dinoflagellates accumulate and crystallize nitrogen-rich molecules from aqueous solutions and use these crystals for growth. This behavior might have implications for understanding marine nitrogen cycling. Moreover, the crystallization behavior can be manipulated to biosynthesize difficult-to-crystallize reflective materials with tailored morphologies and optical properties.

A digital CRISPR-based platform that combines reaction kinetics measurement with machine learning enables accurate quantification of pathogenic fungi and their drug-resistant mutants.

The wearability of conventional artificial kidneys is limited by their dependence on large volumes of dialysate required for dialysis to remove excess water and toxins from the blood. Now, a dialysate-free wearable artificial kidney prototype employs vapor-driven water removal and adsorption to clear toxins. This system achieves a high water clearance rate in renal replacement therapy in animal models.

Microbes naturally grow exponentially, but linear growth may be desirable for some therapeutic applications of genetically modified microorganisms. Here the authors engineered linear growth in E. coli by making division dependent on the asymmetric inheritance of a protein aggregate.

We show that dinoflagellates accumulate and crystallize nitrogen-rich molecules from aqueous solutions and use these crystals for growth. This behavior might have implications for understanding marine nitrogen cycling. Moreover, the crystallization behavior can be manipulated to biosynthesize difficult-to-crystallize reflective materials with tailored morphologies and optical properties.

Isomorphic Lab’s proprietary drug-discovery model is a major advance, but scientists developing open-source tools are left guessing how to achieve similar results.

A digital CRISPR-based platform that combines reaction kinetics measurement with machine learning enables accurate quantification of pathogenic fungi and their drug-resistant mutants.

The soft robotic devices could be used to deliver drugs directly to internal tissues.

The wearability of conventional artificial kidneys is limited by their dependence on large volumes of dialysate required for dialysis to remove excess water and toxins from the blood. Now, a dialysate-free wearable artificial kidney prototype employs vapor-driven water removal and adsorption to clear toxins. This system achieves a high water clearance rate in renal replacement therapy in animal models.