Computational biology and bioinformatics articles from across Nature Portfolio

Computational biology and bioinformatics is an interdisciplinary field that develops and applies computational methods to analyse large collections of biological data, such as genetic sequences, cell populations or protein samples, to make new predictions or discover new biology. The computational methods used include analytical methods, mathematical modelling and simulation.

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AI offers way to image and assess clinical cell samples

The use of artificial intelligence in the clinic to image slides of cells enables the rapid assessment of cellular characteristics that might help with diagnostic decisions.
- Yinuo Xu
- Zhi Huang
News & Views18 Feb 2026 Nature
AI succeeds in diagnosing rare diseases

An artificial-intelligence system uses clinical data, genetic information and literature searches to suggest diagnoses and provides the underlying reasoning.
- Timo Lassmann
News & Views18 Feb 2026 Nature
Identifying spatial single-cell-level interactions with graph transformer

Identifying cell–cell interactions from imaging-based spatial transcriptomics suffers from limited gene panels. A new self-supervised graph transformer-based method can resolve spatial single-cell-level interactions without requiring known ligand–receptor pairs.
- Xiangzheng Cheng
- Suoqin Jin
News & Views06 Feb 2026 Nature Machine Intelligence
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Latest Research and Reviews

LICHEN enables light-chain immunoglobulin sequence generation conditioned on the heavy chain and experimental needs

LICHEN is a computational approach for generating antibody light sequences conditioned on a heavy chain, with optional germline and antigen-binding constraints. In vitro validation confirms LICHEN’s value across antibody engineering scenarios.
- Henriette L. Capel
- Isaac Ellmen
- Charlotte M. Deane
ResearchOpen Access21 Feb 2026 Communications Biology
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Comparative study of wavelet transform and Fourier domain filtering for medical image denoising
- M. Ali Saif
- Bassam M. Mughalles
- Ibrahim G. H. Loqman
ResearchOpen Access21 Feb 2026 Scientific Reports
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Utilizing bulk and single-cell RNA sequencing to identify potential biomarkers linked to angiogenesis and integrated stress response in chondrosarcoma
- Shihong Li
- Jian Zhao
- Cairu Wang
ResearchOpen Access21 Feb 2026 Scientific Reports
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A large-scale benchmark for evaluating large language models on medical question answering in Romanian
- Ana-Cristina Rogoz
- Radu Tudor Ionescu
- Andreea Iuliana Ionescu
ResearchOpen Access21 Feb 2026 npj Digital Medicine
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Spatial perturb-seq: single-cell functional genomics within intact tissue architecture

Spatial CRISPR screens probe the functional impact of mutations within intact tissues. Here, authors present Spatial Perturb-Seq, a technology that localizes CRISPR perturbations and cell identities in situ, uncovers communication between cells, and shows how genes act beyond their cellular borders.
- Kimberle Shen
- Wan Yi Seow
- Wei Leong Chew
ResearchOpen Access21 Feb 2026 Nature Communications
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CMT-Unet: leveraging stage-wise hybrid framework for enhanced accuracy and efficiency in medical image segmentation
- Ru Wang
- Hai Liu
- Gang Wang
ResearchOpen Access21 Feb 2026 Scientific Reports
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News and Comment

AI stethoscope trial highlights the perils of implementation gaps

When used as intended, an AI stethoscope enhanced the detection of cardiovascular disease — but low uptake and workflow challenges hampered effectiveness in a large pragmatic trial.
- Karen O’Leary
Research Highlights20 Feb 2026 Nature Medicine
AI is threatening science jobs. Which ones are most at risk?

Data-analysis and modelling positions are already becoming obsolete, but hands-on experimentalists can breathe easy for now.
- Edward Chen
News20 Feb 2026 Nature
‘An AlphaFold 4’ – scientists marvel at DeepMind drug spin-off’s exclusive new AI

Isomorphic Lab’s proprietary drug-discovery model is a major advance, but scientists developing open-source tools are left guessing how to achieve similar results.
- Ewen Callaway
News19 Feb 2026 Nature
AI offers way to image and assess clinical cell samples

The use of artificial intelligence in the clinic to image slides of cells enables the rapid assessment of cellular characteristics that might help with diagnostic decisions.
- Yinuo Xu
- Zhi Huang
News & Views18 Feb 2026 Nature
AI succeeds in diagnosing rare diseases

An artificial-intelligence system uses clinical data, genetic information and literature searches to suggest diagnoses and provides the underlying reasoning.
- Timo Lassmann
News & Views18 Feb 2026 Nature
Will self-driving ‘robot labs’ replace biologists? Paper sparks debate

AI-driven autonomous robots are coming to biology laboratories, but researchers insist that human skills remain essential.
- Ewen Callaway
News18 Feb 2026 Nature