Pathogenesis articles from across Nature Portfolio

Rapidly progressive glomerulonephritis refers to a group of severe autoimmune kidney diseases. Using high-resolution spatial transcriptomics, we identified a common pathway of disease progression and uncovered sequential PDGF and TGFβ activation of parietal epithelial cells as critical drivers of glomerulonephritis. Our study provides valuable insights that could result in disease stage-specific treatment options.

Rapidly progressive glomerulonephritis refers to a group of severe autoimmune kidney diseases. Using high-resolution spatial transcriptomics, we identified a common pathway of disease progression and uncovered sequential PDGF and TGFβ activation of parietal epithelial cells as critical drivers of glomerulonephritis. Our study provides valuable insights that could result in disease stage-specific treatment options.

Findings demonstrate that STING mediates necroptosis in the context of autoinflammatory disease, and suggest a potential therapeutic approach.

Although DADA2 is typically described as an autosomal recessive disease, it can also present in individuals who are heterozygous for specific ADA2 variants.

In the mouse ischaemic myocardium, neutrophils promote ventricular tachycardia via the secretion of resistin-like molecule-γ, according to a new study published in Science.