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Imaging mass cytometry maps the peri-lesional microenvironment in medication-related osteonecrosis of the jaw, revealing altered immune spatial organization, impaired epithelial regeneration, and differed functional profiling
Comparing dermatomyositis with cutaneous lupus erythematosus, single-cell analysis identifies monocyte-mediated endothelial injury as a dermatomyositis-specific feature and highlights JAK1 inhibition as a potential therapeutic approach.
In a study published in Nature, Liberles and colleagues demonstrate that vagal PIEZO2 neurons in the heart respond to shifts in circulating blood volume to stabilize blood pressure during changes in posture.
Treatment with low-dose IL-2 increases regulatory T cell numbers and reduces arterial inflammation in patients with an acute coronary syndrome and residual systemic inflammation compared with placebo, according to findings from the IVORY trial.
