Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Conditions Limiting Multiplication of Fibroblastic and Epithelial Cells in Dense Cultures

Nature volume 246, pages 197–199 (1973) Cite this article

Abstract

The multiplication of epithelial cells in plastic dishes is limited by the amount of plastic surface available per cell, that of fibroblastic cells by the availability of medium factors. Contacts between cells do not appear to limit the multiplication of either cell type. The multiplication of fibroblastic cells is even favoured by shorter intercellular distances, suggesting a distance-dependent helper effect between cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Stoker, M., and Rubin, H., Nature, 215, 171 (1967).

    Article  ADS  CAS  Google Scholar 

  2. Todaro, G. J., Lazar, G., and Green, H., J. cell. comp. Physiol., 66, 325 (1965).

    Article  CAS  Google Scholar 

  3. Dulbecco, R., and Stoker, M. G. P., Proc. natn. Acad. Sci. U.S.A., 66, 204 (1970).

    Article  ADS  CAS  Google Scholar 

  4. Dulbecco, R., Nature, 227, 802 (1970).

    Article  ADS  CAS  Google Scholar 

  5. Holley, R. W., and Kiernan, J. A., Proc. natn. Acad. Sci. U.S.A., 60, 300 (1968).

    Article  ADS  CAS  Google Scholar 

  6. Todaro, G. J., and Aaronson, S. A., Virology, 38, 174 (1969).

    Article  CAS  Google Scholar 

  7. Stoker, M. G. P., and Abel, P., Cold Spring Harb. Symp. quant. Biol., 27, 375 (1962).

    Article  CAS  Google Scholar 

  8. Jensen, F. C., Girardi, A. J., Gilden, R. V., and Koprowski, H., Proc. natn. Acad. Sci. U.S.A., 52, 53 (1964).

    Article  ADS  CAS  Google Scholar 

  9. Hopps, H. E., Berbeim, B. C., Nisalak, A., Tijo, J. H., and Smadel, J. E., J. Immun., 91, 416 (1963).

    CAS  PubMed  Google Scholar 

  10. Todaro, G. J., and Green, H., Science, N.Y., 147, 513 (1965).

    Article  ADS  CAS  Google Scholar 

  11. Stoker, M. G. P., Nature, 246, 200, (1973).

    Article  ADS  CAS  Google Scholar 

  12. Dulbecco, R., in Growth Control in Cell Cultures (edit. by Wolstenholme, G. E. W., and Knight, J.), 203 (Churchill Livingstone, Edinburgh and London, 1971).

    Google Scholar 

Download references

Author information

Author notes

  1. R. DULBECCO: R. Dulbecco is also a fellow of The Salk Institute, La Jolla, California.

Authors and Affiliations

  1. Imperial Cancer Research Fund, Lincoln's Inn Fields, London, WC2

    R. DULBECCO & J. ELKINGTON

Authors
  1. R. DULBECCO
    View author publications

    Search author on:PubMed Google Scholar

  2. J. ELKINGTON
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

DULBECCO, R., ELKINGTON, J. Conditions Limiting Multiplication of Fibroblastic and Epithelial Cells in Dense Cultures. Nature 246, 197–199 (1973). https://doi.org/10.1038/246197a0

Download citation

  • Received:

  • Revised:

  • Issue date:

  • DOI: https://doi.org/10.1038/246197a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing