Fig. 5: Downregulation of enhanced channel activity of WT-p.G319D tandem concatemers by a KCNQ inhibitor or screening of PIP2. | Experimental & Molecular Medicine

Fig. 5: Downregulation of enhanced channel activity of WT-p.G319D tandem concatemers by a KCNQ inhibitor or screening of PIP2.

From: Novel KCNQ4 variants in different functional domains confer genotype- and mechanism-based therapeutics in patients with nonsyndromic hearing loss

Fig. 5: Downregulation of enhanced channel activity of WT-p.G319D tandem concatemers by a KCNQ inhibitor or screening of PIP2.The alternative text for this image may have been generated using AI.

Linopirdine (3–10 μM) inhibition of WT-p.G319D concatemer current is presented with I-V curves a and activation curves b. In the absence c, d or presence e, f of PIP5K expression, intracellularly applied poly-L-lysine (PLL, 10 or 30 μg/ml) attenuated the WT-p.G319D concatemer current c, e, with a concomitant shift of activation curves toward positive potentials d, f. The reducing effects of linopirdine and PLL on the WT-p.G319D channel current (n = 10) were compared with the effects on the WT-WT current (n = 6). Mean ± SEM.

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