Fig. 1: Overall structure of CRF1R with BMK-I-152. | Experimental & Molecular Medicine

Fig. 1: Overall structure of CRF1R with BMK-I-152.

From: Structure-based drug discovery of a corticotropin-releasing hormone receptor 1 antagonist using an X-ray free-electron laser

Fig. 1: Overall structure of CRF1R with BMK-I-152.The alternative text for this image may have been generated using AI.

a Cartoon representation of the CRF1R and BMK-I-152 complex. CRF1R (residues 104–368) and BMK-I-152 are colored green and yellow, respectively. CRF1R utilizes the following major interaction networks: the b central hydrogen bond network, c hydrophobic network, and d inactive state stabilizing network. BMK-I-152 is in the hydrophobic network.

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