Table 5 Meta-analysis results for ratios of means and mean differences in anthropometric and body composition parameters after 12 months of GLP-1 RA therapy.

From: GLP-1 agonists and changes in body mass and composition in adults with overweight or obesity with or without type 2 diabetes mellitus: a systematic review and meta-analysis

Study	GLP-1 RA		SE	−95%CI	+95%CI	p-value	weight [%]
RoM of Body mass
Capristo et al. [25]	Liraglutide	0.76	0.04	0.69	0.84	<0.001*	49.45
Vedtofte et al. [70]		0.95	0.04	0.87	1.04	0.238	50.55
		0.85	0.09	0.69	1.05	0.138	100.00
Pantanetti et al. [68]	Semaglutide	0.94	0.01	0.93	0.96	<0.001*	100.00
Yabe et al. [71]	Dulaglutide	0.99	0.01	0.97	1.01	0.375	100.00
Summary (random effects)		0.96	0.01	0.95	0.97	<0.001*
Intergroup comparison						<0.001*
Egger’s test						0.587
MD of Body mass index [kg/m²]
Capristo et al. [25]	Liraglutide	−9.72	0.46	−10.62	−8.82	<0.001*	49.94
Vedtofte et al. [70]		−1.70	0.37	−2.42	−0.98	<0.001*	50.06
		−5.71	4.01	−13.56	2.15	0.155	100.00
Pantanetti et al. [68]	Semaglutide	−1.74	0.07	−1.89	−1.59	<0.001*	100.00
Summary (random effects)		−1.74	0.07	−1.89	−1.60	<0.001*
Intergroup comparison						0.323
Egger’s test						0.495
MD of Waist circumference [cm]
McCrimmon et al. [67]	Semaglutide	−3.9	0.9	−5.7	−2.1	<0.001*	31.54
Pantanetti et al. [68]		−2.4	0.2	−2.7	−2.1	<0.001*	68.46
		−2.9	0.7	−4.2	−1.5	<0.001*	100.00
Vedtofte et al. [70]	Liraglutide	−3.4	0.7	−4.7	−2.1	<0.001*	100.00
Summary (random effects)		−3.2	0.5	−4.1	−2.2	<0.001*
Intergroup comparison						0.575
Egger’s test						0.019*
RoM of Fat body mass
Capristo et al. [25]	Liraglutide	0.71	0.04	0.63	0.80	<0.001*	100.00
McCrimmon et al. [67]	Semaglutide	0.90	0.04	0.83	0.97	0.007*	37.51
Pantanetti et al. [68]		0.97	0.01	0.95	0.99	0.016*	62.49
		0.94	0.03	0.88	1.01	0.103	100.00
Yabe et al. [71]	Dulaglutide	0.99	0.02	0.95	1.03	0.639	100.00
Summary (random effects)		0.96	0.02	0.92	0.99	0.007*
Intergroup comparison						< 0.001*
Egger’s test						0.160
RoM of Lean body mass
Capristo et al. [25]	Liraglutide	0.85	0.05	0.75	0.96	0.010*	100.00
McCrimmon et al. [67]	Semaglutide	0.96	0.02	0.92	1.00	0.036*	10.40
Pantanetti et al. [68]		0.94	0.01	0.93	0.95	<0.001*	89.60
		0.94	0.01	0.93	0.95	<0.001*	100.00
Yabe et al. [71]	Dulaglutide	0.99	0.01	0.98	1.01	0.526	100.00
Summary (random effects)		0.96	0.01	0.95	0.97	<0.001*
Intergroup comparison						<0.001*
Egger’s test						0.801

^*statistical significance.

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Table 5 Meta-analysis results for ratios of means and mean differences in anthropometric and body composition parameters after 12 months of GLP-1 RA therapy.

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