Fig. 3: HNRNPA2B1 regulates the alternative splicing and promotes invasive behavior of head and cancer cells. | Laboratory Investigation

Fig. 3: HNRNPA2B1 regulates the alternative splicing and promotes invasive behavior of head and cancer cells.

From: The HNRNPA2B1–MST1R–Akt axis contributes to epithelial-to-mesenchymal transition in head and neck cancer

Fig. 3: HNRNPA2B1 regulates the alternative splicing and promotes invasive behavior of head and cancer cells.The alternative text for this image may have been generated using AI.

Semiquantitative PCR to analysis of HNRNPA2B1 target gene. a WWOX exon 6–8 inclusion/skipping. b CFLAR exon 7 inclusion/skipping. c Pictorial diagram to show differential splicing pattern of MST1R in HNC cells. d MST1R exon 11 inclusion/skipping. e MST1R-minigene transfection and fluorescence analysis in control and HNRNPA2B1-depleted H413 HNC cells, oral cancer cells. Scale bar = 200 µm. f Immunoblotting of HNRNPA2B1, pAkt, pan Akt, E-cadherin, vimentin, and GAPDH in control and HNRNPA2B1-depleted H413 cells.

Back to article page