Fig. 2: Brain regions showed variations in susceptibility to volume changes due to immune system mutations.

A The probability of a brain region having a large effect size (d) magnitude in mutant strains. Probability of effect-sizes (x-axis) for various structures—B midbrain, C corpus callosum, D dorsal striatum, E thalamus—across the different mutant strains (y-axis), for both female (F) and male (M) mice. Vertical dashed lines represent effect sizes of ±1, and probability within this interval is shaded grey. Integrating the area of the probability density outside this interval (pink) provides the probability that immune system mutations result in a large effect-size magnitude. These four structures had the highest probability of large effect size magnitudes.