Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Spatiotemporal profiling reveals distinct dynamics and checkpoint regulations of CAR-T and CAR-NKT cells against solid tumors

Fig. 2The alternative text for this image may have been generated using AI.

CAR-T and CAR-NKT cells exhibit distinct in vivo pharmacokinetics and pharmacodynamics (PK/PD) during antitumor response. a Experimental design to study the in vivo PK/PD in an OVCAR8 human ovarian cancer xenograft NSG mouse model. Note the therapeutic cells, but not the OVCAR8 tumor cells, were labeled with the FG. b BLI images showing the presence of therapeutic cells in experimental mice over time. c Quantification of (b) (n = 3). d Representative BLI images showing the biodistribution of therapeutic cells in the indicated experimental mice. e Quantification of the tissue distribution of therapeutic cells (n = 3). F.D. found dead. f FACS detection of CAR-T and CAR-NKT cells in the peritoneal fluid and blood of the experimental mice over time. g Quantification of (f) (n = 5). Representative of 2 experiments. Data are presented as the mean ± SEM. ns not significant, ****p < 0.0001, by Student’s t test (e)

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