Fig. 1: Example on longitudinal response monitoring using QIP-MS and immunofixation. | Blood Cancer Journal

Fig. 1: Example on longitudinal response monitoring using QIP-MS and immunofixation.

From: Implications and prognostic impact of mass spectrometry in patients with newly-diagnosed multiple myeloma

Fig. 1: Example on longitudinal response monitoring using QIP-MS and immunofixation.The alternative text for this image may have been generated using AI.

Exemplary case showing the immunofixation (IFE) results, IMWG response and QIP-MS spectra for the monoclonal intact immunoglobulin and free light chain at selected time points. In this patient, QIP-MS also identified a monoclonal IgG kappa (m/z = 11577) + free kappa (m/z = 11582) at baseline, indicating the presence of a patient-specific clone co-expressing monoclonal intact immunoglobulin and free light chain. During maintenance/observation (after 24 months) the patient achieved a complete response (CR) while remaining QIP-MS positive. * serum IFE # according to IMWG criteria [15], IFE immunofixation, IMWG International Myeloma Working Group, PR partial response, VGPR very good partial response, CR complete response.

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