Fig. 1: Efficacy analysis.

A Response rates at mid-induction; B Response rates at the end of induction therapy; C The best response rates recorded throughout the trial; D A Sankey diagram illustrating the relationship between treatment efficacy and patient outcomes; and E Swim-lane plots showing the duration of treatment and corresponding responses. Note: Efficacy assessments at the end of induction therapy were inconclusive for six patients. Five of these patients had not yet finished their induction regimen, while one patient discontinued prematurely due to dissatisfaction with the PR achieved. The best response observed during the trial was ambiguous for three patients. Two patients, who had achieved a PR at the mid-induction evaluation, were still in treatment with the possibility of achieving a CR remaining uncertain. One patient withdrew from the study prematurely due to dissatisfaction with the PR, which was an unplanned event. CI confidence interval, DCR disease control rate, ORR overall response rate, CR complete remission, PR partial remission, SD stable disease, PD progressive disease, NE not evaluable, GCB germinal center B-cell-like, ASCT autologous hematopoietic stem cell transplantation.