Table 1 Baseline characteristics of participants.

From: Prospective phase II trial of first-line rituximab, methotrexate, and orelabrutinib (R-MO) in primary central nervous system lymphoma

Characteristics

All (N = 37)

Median age, year, median (range)

62 (27, 78)

Age, year, n (%)

 ≤60

16 (43.2)

 >60

21 (56.8)

Sex, n (%)

 Male

18 (48.6)

 Female

19 (51.4)

Pathological types, n (%)

 Non-GCB DLBCL

25 (67.6)

 GCB DLBCL

12 (32.4)

Double-expressor lymphomasa, n (%)

 Yes

12 (32.4)

 No

25 (67.6)

Ki67, %, median (range)

80 (60, 95)

Multiple lesions, n (%)

 Yes

23 (62.2)

 No

14 (37.8)

Deep brain lesionsb, n (%)

 Yes

27 (73)

 No

10 (27)

Concurrent sites, n (%)

 Leptomeningeal

2 (5.4)

 Spinal cord

1 (2.7)

 Intra-ocular

1 (2.7)

Lactate dehydrogenase, n (%)

 Elevated

6 (16.2)

 Normal

31 (83.8)

CSF Protein, n (%)

 Elevated

13 (35.1)

 Normal

24 (64.9)

ECOG PS, n (%)

 1

14 (37.8)

 2

21 (56.8)

 3

2 (5.4)

IELSG scoring system, n (%)

 Low risk

6 (16.2)

 Intermediate risk

27 (73)

 High risk

4 (10.8)

MSKCC scoring system, n (%)

 Low risk

5 (13.5)

 Intermediate risk

16 (43.2)

 High risk

16 (43.2)

Diagnosis modality, n (%)

 Stereotactic/open biopsy of intracranial lesions

14 (37.8)

 Maximal safe resection of intracranial lesions

23 (62.2)

  1. GCB germinal center B-cell-like, DLBCL diffuse large B-cell lymphoma, CSF cerebrospinal fluid, ECOG PS Eastern Cooperative Oncology Group performance status, IELSG International Extranodal Lymphoma Study Group, MSKCC Memorial Sloan-Kettering Cancer Center.
  2. aDouble-expressor lymphomas were defined as ≥40% MYC expression and ≥50% BCL-2 expression in tumor cells, as assessed by immunohistochemistry.
  3. bDeep brain lesions were defined as those involving the periventricular zone, basal ganglia, corpus callosum, brainstem, and cerebellum.