Fig. 6: Mutational profiles across different sites of onset in PCNSL.

A The number and percentage of PCNSL patients with various molecular subtypes at different disease onset sites. B Venn diagram of unique and shared mutations among PCNSLs with different sites of onset. C The number and frequency of recurrent mutations, along with a gene‒sample matrix of recurrently mutated genes in PCNSL patients at different sites of onset, are presented. The relative abundance across the molecular subtypes is displayed on the right. D Arm-level copy number alterations across different sites of onset are displayed. The frequencies of amplifications and deletions were compared. E The levels of mutant-allele tumor heterogeneity (MATH) were compared among the samples representing different sites of onset. F Comparisons of the tumor mutational burden (TMB) among the different sites of onset samples were performed. G The levels of microsatellite instability (MSI) were compared among the samples representing different sites of onset. H Pathways affected by oncogenes in PCNSL patients with different sites of onset. The chi-squared test and one-way ANOVA were used. *P < 0.05. Comparisons without asterisks are not statistically significant (P > 0.05).