Fig. 5 | Bone Research

Fig. 5

From: Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy

Fig. 5The alternative text for this image may have been generated using AI.

Estradiol treatment in Orx male-to-female mice increases trabecular bone accrual by stimulating bone formation. a Osteoclast number/bone perimeter [(N.Oc./B.Pm)/(No./mm−1)], (b) osteoclast surface/bone surface ((Oc.S/BS)/%), (c) mineralizing surface/bone surface ((MS/BS)/%), (d) mineral apposition rate (MAR/(μm/d)), (e) bone formation rate (BFR/(μm2/μm/d)) in the distal femoral metaphysis of male controls (n = 4 for (a, b), n = 7 for (c–e)) and Orx males (n = 4 for (a, b), n = 6 for (c–e)) 3 weeks post-surgery (8 weeks of age) and in female controls (n = 7–8), male controls (n = 9), Orx males (n = 7) and Orx males administered estradiol (male Orx + estradiol) (n = 5–6) at 3 weeks post-surgery (8 weeks of age) for 12 weeks (20 weeks of age). *P < 0.05, **P < 0.005, ***P < 0.000 5. Shown are individual values, medians, interquartile ranges, and minimum and maximum values

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