Fig. 6
From: TGF-β-induced fibrotic scar formation limits recovery of spinal cord injury
Single-cell RNA-seq reveals elevated active TGF-β-induced fibroblast differentiation of MSCs after SCI. a Clustered and annotated data from all sample groups (1D11, 13C4, and Sham) plotted on UMAP coordinates and identifying the indicated cell types. b UMAP plot of cell type annotations split by sample group. c Heat map of enriched expression of TGF-β pathway genes in pericytes from the 1D11 versus 13C4 sample groups. d–g Violin plots of TGF-β ligand and receptor expression across cell types, split by sample group. h Dot plot of the mean expression and fraction of cells in each sample group expressing three key axon growth regulators: two growth inhibitors (Sema3a and Ephb2) and one growth factor (Cd248). i Dot plot of significant (P < 0.05) ligand-receptor interactions between cell types of interest, as determined by CellPhoneDB
