Fig. 6 | British Journal of Cancer

Fig. 6

From: Inhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs

Fig. 6The alternative text for this image may have been generated using AI.

Intraoperative ketorolac induces p53 acetylation at the K382 site in clinical settings. a Model of the NSAIDs and exisulind chemopreventive action: the direct inhibition of SIRT1 leads to the unbalance activity of p53 involved in the early steps of tumourigenesis. A genotoxic stress increases proliferation (left panel, − NSAIDs) which is counteracted by NSAIDs (right panel, + NSAIDs). b Immunoblot analysis was carried out using anti-acetyl (K382) p53 and anti-total p53 antibodies and protein extracts obtained from 13 patients: six were treated with ketoroloac (20 mg per os) 2 h before surgery and seven with opiates for intraoperative analgesia. β-actin is reported as loading control. Bars in the graphs represents densitometry quantifications of the autoradiographic signals (acetylated p53 vs total p53); ***P < 0.001 versus the level of control; P-values were calculated by Student’s t-test

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