Fig. 5 | British Journal of Cancer

Fig. 5

From: High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer

Fig. 5The alternative text for this image may have been generated using AI.

FABP7 knockdown induces the alteration of PD-1-related gene expression profile and PI composition in HCC1806 cells. a The pathways related to the immune response that are differentially activated in HCC1806 cells with or without FABP7 knockdown. The “–Log (p-value)” of each pathway is shown. b A heatmap illustrating the expression of individual genes related to “inhibitory PD-1 signalling in T cells”. Gene expression values are indicated by a blue to yellow colour scale (top bar). The analysis was performed in biological triplicate. c Flow cytometry analysis of PD-L1 expression. The x axis represents PD-L1 expression. The PD-L1-positive population was determined relative to the negative control peak (blue). d The difference of FA composition of PIs between HCC1806 cells with and without FABP7 knockdown. * indicates a statistically significant difference in the comparison two-way ANOVA with Sidak’s post hoc multiple comparisons test. **p < 0.01; ***p < 0.001; ****p < 0.0001. e The graphical abstract of this study.

Back to article page