Fig. 7: PTPRM knockdown suppresses the lymphangiogenesis and LNM of CCa in vivo. | Cell Death & Disease

Fig. 7: PTPRM knockdown suppresses the lymphangiogenesis and LNM of CCa in vivo.

From: High expression of PTPRM predicts poor prognosis and promotes tumor growth and lymph node metastasis in cervical cancer

Fig. 7: PTPRM knockdown suppresses the lymphangiogenesis and LNM of CCa in vivo.The alternative text for this image may have been generated using AI.

a The representative pictures of popliteal lymph nodes (n = 10 per group). b, c Histogram analysis of the average popliteal lymph nodes volume and the rate of LNM in different treatment groups. d The representative pictures of H-E staining of positive and negative metastatic popliteal lymph nodes and inguinal lymph nodes. Original magnification: ×100. e Representative IHC pictures of intratumoral and peritumoral lymphatic vessels in the primary tumors resected from footpads of nude mice stained by anti-LYVE-1 in the mice bearing PTPRM-silenced cells and control group (left panel), quantification of LYVE-1 positive vessels in primary tumors (right panel). Original magnification: ×200. *, ** or ***: significantly different from the corresponding control, P < 0.05, P < 0.01 or P < 0.001, respectively.

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