Fig. 6: Schematic summary of the main findings in this study. | Cell Death & Disease

Fig. 6: Schematic summary of the main findings in this study.

From: Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish

Fig. 6: Schematic summary of the main findings in this study.The alternative text for this image may have been generated using AI.

Depletion of Tulp1a and Tulp1b in zebrafish diminished the transcriptional activity of tekt2, which impaired the ciliogenesis of photoreceptors, and thus interfering the trafficking of opsins. Eventually, ferroptosis was activated in photoreceptors, and retina was degenerated.

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