Fig. 4: Genome-wide transcriptional profile analysis of DS-NCSCs. | Cell Death & Disease

Fig. 4: Genome-wide transcriptional profile analysis of DS-NCSCs.

From: Migration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model

Fig. 4: Genome-wide transcriptional profile analysis of DS-NCSCs.The alternative text for this image may have been generated using AI.

a Pearson’s correlation coefficients of pairwise comparisons were calculated for all expressed genes in NCSCs derived from the control group and the DS group. b IPA functional annotation of all differentially expressed mRNAs. The dot plot of partially enriched functions. The color intensity of the nodes indicates the degree of IPA function enrichment. The horizontal axis indicates the gene ratio as the proportion of differentially expressed genes in the whole gene set. The size represents the number counts in a certain function. c IPA canonical pathway analysis of all differentially expressed mRNAs. The dot plot of partially enriched pathways. The color intensity of the nodes indicates the degree of canonical IPA pathway enrichment. The horizontal axis indicates the gene ratio as the proportion of differentially expressed genes in the whole gene set. The size represents the number counts in a certain pathway. d The top 50 genes with upregulated expression on HSA21 in the DS group compared to the control group.

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