Fig. 4: G6PD plays a crucial role in the proliferation of HCC. | Cell Death & Disease

Fig. 4: G6PD plays a crucial role in the proliferation of HCC.

From: Matrix stiffness regulates glucose-6-phosphate dehydrogenase expression to mediate sorafenib resistance in hepatocellular carcinoma through the ITGB1-PI3K/AKT pathway

Fig. 4: G6PD plays a crucial role in the proliferation of HCC.The alternative text for this image may have been generated using AI.

A Comparison of the viability of HCC-LM3 and HepG2 cells between the control group and the G6PD-silenced group. B Effects of knocking down G6PD on the growth of HCC-LM3 and HepG2 cells, as determined by plate colony formation assays. C The effect of knocking down G6PD on subcutaneous xenograft growth. Statistical analysis of subcutaneous tumor weight (D) and tumor volume (E) in the control and G6PD-knockdown groups; scale bar: 1 cm. F The effect of overexpressing G6PD on the growth of HCC-LM3 and HepG2 cells was evaluated via a CCK8 assay. G A plate colony formation assay revealed the effect of overexpressing G6PD on HCC-LM3 and HepG2 cell growth. H Growth of subcutaneous tumors in the control group and the G6PD-overexpression group. Statistical analysis of subcutaneous tumor weight (I) and tumor volume (J) in the control groups and the G6PD-overexpression groups; scale bar: 1 cm; **P < 0.01, ***P < 0.001, and ****P < 0.0001.

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