Fig. 5: Effect of C4BPA on myotube differentiation in 3D culture. | Cell Death & Disease

Fig. 5: Effect of C4BPA on myotube differentiation in 3D culture.

From: Impact of C4BPA on Muscle progenitor cell differentiation: insights for Duchenne muscular dystrophy treatment

Fig. 5: Effect of C4BPA on myotube differentiation in 3D culture.The alternative text for this image may have been generated using AI.

A Timeline scheme of the differentiation of the 3D culture with C4BPA treatment. B Representative cross-sectional image of a 3D muscle, untreated and treated with C4BPA. Staining corresponds to SAA, F-actinin and nuclei of tissues. C Bar graph showing myotube cross-section area (µm2) and Feret diameter (µm) after 10 days myoblasts differentiation with and without C4BPA treatment. D Bar graph showing the total number of myotubes measured per mm2 or by tissue. E Bar graph showing contractile dynamics of the 3D muscle tissue after 10 days of differentiation. Twitch force (µN/mm2), tetanic force (µN/mm2), tetanic/twitch index, time in peak (seconds) and time to peak (seconds) parameters were measured. Data are shown as means ± SD; Statistical significance was set at P < 0.05, **P < 0.01.

Back to article page