Table 2 Comparison of MIC activity of MIE-EEPS peptide vs. MIE-EEPS peptide-vancomycin conjugate vs. admixture of MIE-EEPS peptide plus vancomycin
From: Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria
Structure | MIC (µg mL-1) S. aureus MRSA ATCC 43300 | MIC (µg mL-1) E. faecium MDR VanA ATCC 51559 | |||||
|---|---|---|---|---|---|---|---|
MIE-EEPSa peptide | Vanc conj. | MIE-EEPS peptideb | MIE-EEPS peptide/vanc mixture (1:1) | Vanc conj. | MIE-EEPS peptideb | MIE-EEPS peptide/vanc mixture (1:1) | Vanc conj. |
Vanc | 1 | 1 | >64 | ||||
8ac | 8 | >8 | 4 | 0.5 | >8 | 4 | 0.125 |
12ad | 12 | >8 | 4 | 0.09 | >8 | 4 | 0.007 |
13ae | 13 | >8 | 4 | 0.011 | >8 | 4 | 0.02 |
14af | 14 | >8 | 4 | <0.003 | >8 | 4 | 0.09 |
15ag | 15 | >8 | 4 | <0.003 | >8 | 4 | 0.02 |
