Fig. 3

Classification of cellular response to single and combinatorial perturbations. a Network similarity-based clustering of 45 differentially wired networks. They were divided into three subgroups (subgroup 1: green, subgroup 2: pink, subgroup 3: yellow). b A major cellular response phenotype of cancer network after drug treatment is compared with that before drug treatment to identify the presence or absence of “critical target”. Also, it is compared with a major cellular phenotype of control (normal) network to identify the presence or absence of “critical determinant”. c, d Based on results of the attractor landscape analysis, heterogeneous drug responses of the 45 p53 network subtypes from the 83 human cancer cell lines were classified into eight distinct response groups by three criteria, including the major drug response phenotype (P/A/D), the presence or absence of critical target, and the presence or absence of the set of critical genomic determinant