Fig. 5 | Nature Communications

Fig. 5

From: Network dynamics-based cancer panel stratification for systemic prediction of anticancer drug response

Fig. 5The alternative text for this image may have been generated using AI.

Experimental validation of the drug response profiles of eight cancer cell lines in the panel. a Differentially wired networks corresponding to the eight distinct cancer cell lines (A549 (lung, DWN_3_11), MCF7 (breast, DWN_3_8), U2OS (bone, DWN_3_12), A375 (skin, dwn_2_7), 769p (kidney, DWN_2_3), SJSA1 (bone, DWN_3_1), CAL51 (breast, DWN_2_4), A2780 (ovary, DWN_3_5). b Predicted major drug response phenotype and the associated critical determinant for the eight cell line-specific networks in response to various perturbations. c Scatter plots of the experimentally observed vs. predicted cell death ratio for all cell lines combined and each individual cell line. The error bars indicate the standard deviation of time-lapse imaging experiments under various drug treatment conditions. d Evaluation of drug response prediction results acquired by our network dynamics analysis using Pearson correlation and RMSE. e, f Comparison of the predictive power of our network dynamics analysis and random prediction using Pearson correlation and RMSE

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