Table 2 Significantly mutated genes in SMC
From: Multi-omics profiling of younger Asian breast cancers reveals distinctive molecular signatures
SMC | TCGA | SMC vs. TCGA | |||||
|---|---|---|---|---|---|---|---|
Gene symbol | Gene description | Mut Freq (n=186) | p value | q value | Mut Freq (n=1001) | q value | p value |
TP53 | tumor protein p53 | 89 (47.9%) | 0 | 0 | 320 (32.0%) | 0 | 2.89e-04 |
PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 53 (28.5%) | 0 | 0 | 320 (32.0%) | 2.09e-12 | 0.81 |
GATA3 | GATA binding protein 3 | 23 (12.4%) | 0 | 0 | 91 (9.1%) | 0 | 0.49 |
CBFB | core-binding factor, beta subunit | 5 (2.7%) | 0 | 0 | 21 (2.1%) | 7.85e-07 | 0.83 |
PTEN | phosphatase and tensin homolog | 6 (3.2%) | 6.40e-06 | 0.015 | 44 (4.4%) | 0 | 0.83 |
CDH1 | Cadherin-1 | 4 (2.2%) | 3.64e-05 | 0.076 | 115 (11.5%) | 8.64e-13 | 2.46e-04 |
