Fig. 4 | Nature Communications

Fig. 4

From: Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

Fig. 4The alternative text for this image may have been generated using AI.

Emerging PfCRT mutations modify P. falciparum susceptibility to multiple antimalarial drugs. Mean ± SEM IC50 values (Supplementary Tables 7–10) were calculated from 72-h dose–response assays for drugs designated in a–g. N, n = 4+, 2. Significance was determined using Mann–Whitney U tests comparing pfcrt-edited parasites and their isogenic controls. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; n.s. not significant, md monodesethyl

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