Fig. 4 | Nature Communications

Fig. 4

From: Samarium(II) folding cascades involving hydrogen atom transfer for the synthesis of complex polycycles

Fig. 4The alternative text for this image may have been generated using AI.

Folding radical cascades involving 1,5-HAT and activation of a secondary alkyl group. A samarium(II) folding cascade involving 1,5-HAT activation of secondary alkyl groups in key radical intermediates V is shown. a Scope of the samarium(II) folding cascade involving activation of a secondary alkyl group by 1,5-HAT to give products 7d–j. b The mechanism of folding involves 1,5-HAT in key radical intermediates V to give 9. A 1,2-ester shift then generates radical intermediates 10 that, after hemiketal opening and SET reduction, give samarium(III) enolates 12. The final products 7d–j are obtained by lactonisation of enolates 12

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