Fig. 5 | Nature Communications

Fig. 5

From: Samarium(II) folding cascades involving hydrogen atom transfer for the synthesis of complex polycycles

Fig. 5The alternative text for this image may have been generated using AI.

Folding radical cascades involving 1,5-HAT and activation of a benzylic group. A samarium(II) folding cascade involving activation of benzylic groups by 1,5-HAT in key radical intermediates V is shown. a The scope of the samarium(II) folding cascades involving benzylic group activation by 1,5-HAT to give products 7k–q. b The mechanism of folding involves 1,5-HAT in key radical intermediates V to give 14 and subsequent fragmentation to give ketyl-type radicals 15. Intramolecular acyloin reaction then delivers 16 that undergo diastereoselective reduction to give products 7k–q

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