Fig. 2
Determination of E2-induced TDRCs in MCF7 cells. a An instructive tree of comparing compartments A (Top) and B (Bottom) at E2-induced five time points. T0: control, T1: 1 h; T4: 4 h; T16: 16 h; and T24: 24 h. b A number of compartments at each of 24 individual patterns categorized into six types, including HCC with patterns 1~4; ETC with patterns 5~8; LTC with patterns 9~12; LDC with patterns 13~16; MDC with patterns 17~20; HDC with patterns 21~24. c The variance (σ2) of first eigenvector values of compartment types in T0, T1, T4, T16, T24. The p value was determined by Wilcoxon rank-sum test. d, e Examples of compartment changes, MDC (d) and HDC (e) along E2-induced five time points. Dark: Compartment A; Dark red: Compartment B. Compartments are indicated between green dash lines. Blue dash ovals highlight the dynamic region. TDRC temporally dynamic re-compartmentalization, MDC moderately dynamic compartments, HDC highly dynamic compartments
