Fig. 4
Circos plot showing the (Bonferroni-corrected p < 1.06 × 10−7) results for associations of DNA methylation with birthweight. Results are presented as CpG-specific associations (−log10(P), each dot represents a CpG) by genomic position, per chromosome. From outer to inner track: [1, orange] Main analysis results for associations between DNA methylation and birthweight as a continuous measure (n = 8825), [2, blue] Results from participants from European ethnicity only, DNA methylation and birthweight as a continuous measure (n = 6023), [3, red] Results from analysis without exclusion for preterm births, pre-eclampsia and maternal diabetes, DNA methylation and birthweight as a continuous measure n = 5414), [4, purple] Results from logistic regression analysis without exclusion for preterm births, pre-eclampsia and maternal diabetes, for low (n = 178) vs normal (n = 4197) birthweight, [5, yellow] Results from logistic regression analysis for associations between DNA methylation and high (n = 1590) vs normal (n = 6114) birthweight, [6, green] Results from look-up analysis in methylation samples taken during childhood and its association with birthweight as a continuous measure (n = 2756). Track 1: highlighted in red are 115 CpGs with I2 > 50%. Tracks 2–6: highlighted in red are CpGs that were not found in the 914 main meta-analysis hits (though note differences in sample size and hence statistical power for different analyses presented in the different tracks)
