Fig. 2: ICP27 is sufficient to inhibit RNAPII transcription termination.
From: Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27
a 4sU-seq tracks of KDM4C and SPTSSA genes in cells transfected with vector or an ICP27-expressing plasmid. For comparison, 4sU-seq tracks for cells infected with WT or ΔICP27 HSV-1 were also included. Two replicates for each condition are shown. b Metagene analysis of 4sU-seq signals at the transcript end site (TES) in cells transfected with vector or an ICP27-expressing plasmid or infected with HSV-1. c Venn diagram showing the overlap of genes with significant termination defects in cells infected with HSV-1 or transfected with ICP27 overexpression.
