Fig. 2: SPy_2191 induces humoral immune response. | Nature Communications

Fig. 2: SPy_2191 induces humoral immune response.

From: Cross-serotype protection against group A Streptococcal infections induced by immunization with SPy_2191

Fig. 2: SPy_2191 induces humoral immune response.The alternative text for this image may have been generated using AI.

a Immunization schedule in C57BL/6 mice. b SPy_2191 specific total IgG endpoint titres in sera samples (n = 6 mice) collected 2 weeks after priming (day 14) and booster immunizations (day 28 and 42), was measured by Indirect ELISA. One-way ANOVA followed by Tukey’s multiple-comparison test was employed for calculating the significant difference. Data are presented as mean values ± SEM c Opsonophagocytic activity of SPy_2191 specific antibodies containing sera (n = 4), was evaluated for bactericidal assay, against various GAS serotypes, viz. M1/IND, M49/IND, M3.1/IL, M1/USA, and M1/UK. Percent reduction of CFU by SPy_2191-immunized sera was estimated in comparison to PBS-immunized mice sera, used as control. Data are presented as mean values ±  SEM. ****P < 0.0001.

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