Fig. 1: Cryo-EM structures of BNM-III-170-BG505-17b and M48U1-BG505-17b. | Nature Communications

Fig. 1: Cryo-EM structures of BNM-III-170-BG505-17b and M48U1-BG505-17b.

From: Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation

Fig. 1: Cryo-EM structures of BNM-III-170-BG505-17b and M48U1-BG505-17b.The alternative text for this image may have been generated using AI.

a Top-down view of density maps for BNM-III-170-BG505-17b and M48U1-BG505-17b complexes. b Side view of density maps for BNM-III-170-BG505-17b and M48U1-BG505-17b complexes. Boxed region indicates binding site for one CD4m molecule on each structure. c Close-up views of densities (blue) in CD4m binding sites. Densities are shown at 7σ. Structure colors: 17b variable domain = light blue, gp120 = gray, gp41 = light orange, N-linked glycans = teal, BNM-III-170 = magenta, M48U1 = red, carbon atoms = gray, magenta, or red, oxygen atoms = red, nitrogen atoms = blue, sulfur atoms = yellow, chlorine atoms = green, fluorine atoms = pale blue.

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