Fig. 2: Six non-synonymous mutations plotted onto diphtheria toxin model 1XDT (https://www.rcsb.org/structure/1xdt) from the Protein Data Bank using PHYRE2.
From: Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae

The impact of these mutations is estimated by SuSPect, with a gradient per mutation of low (dark blue) to high (orange/red).