Table 2 Scope of Ni/photoredox-catalyzed coupling of aryl iodides with α-chloroboranesa.

From: Dual Ni/photoredox-catalyzed asymmetric cross-coupling to access chiral benzylic boronic esters

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  1. aReaction conditions: 1 (1.6 equiv.), 2 (0.2 mmol), NiBr2·DME (10 mol%), L1 (12 mol%), 4CzIPN (1 mol%), HEH (2 equiv.), TEA (5 equiv.), DME/DMA (4 mL, v/v = 5/1), Blue LEDs (30 W), 18–25 oC, 8–10 h. Isolated yields were given. The ee values were determined of the corresponding alcohol after oxidation by HPLC.
  2. bIsolated yield and ee of the corresponding alcohol after oxidation were given.
  3. c2a (2.0 equiv.).
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