Fig. 7: Timd4 expression correlations and predictive value in human lung adenocarcinoma. | Nature Communications

Fig. 7: Timd4 expression correlations and predictive value in human lung adenocarcinoma.

From: TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses

Fig. 7: Timd4 expression correlations and predictive value in human lung adenocarcinoma.The alternative text for this image may have been generated using AI.

a Correlation between Timd4 transcripts and gene signatures for cDC1 and cytotoxic T cells (gene signatures described in Supplementary Table 2) within lung adenocarcinoma cases (LUAD) in TCGA. Pearson correlation coefficient in the cor.test function of R stats package with two.sided as alternative hypothesis. b Kaplan–Meier survival curves showing probability of survival for stage-I LUAD cases from the TCGA dataset (n = 219). The two groups with either high or low expression of cDC1 or cDC1 + Timd4, were identified based on the classification rule described in the ref. 60 and detailed in methods. Survival curves were compared using the log-rank (Mantel–Cox) test. c, d Patients from cohort GSE126044 that responded or not to PD-1 therapy were classified based on baseline pre-treatment expression of Timd4 (c), cDC1 and CD8 cytotoxic T cells signatures (d). P values are calculated using the two-tailed Mann–Whitney test; responder n = 5, Non-responder n = 11. Source data are provided as a Source Data file.

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