Fig. 1: CD1 gene expression in leukemia datasets.

Analysis of group 1 and group 2 CD1 expression levels in different types of leukemia from published datasets highlights higher and more uniform expression of CD1c in both adult and pediatric Acute Myeloid Leukemia (AML) and B-Acute Lymphoblastic Leukemia (B-ALL). a Expression level of CD1 genes across a selection of leukemia datasets [adult AML: GSE12417; pediatric AML: GSE17855; adult B-ALL: GSE14834; pediatric B-ALL: GSE13576; adult T-Acute Lymphoblastic Leukemia (T-ALL): GSE14618; pediatric T-ALL GSE50999; the expression levels of CD1 genes in additional datasets are reported in Supplementary Fig. 1a]. Sample size of each dataset is detailed in Supplementary Table 1. b Elevated expression of CD1c in adult B-ALL is preserved in patients not responding to therapies, while its expression remains low in T-ALL at the time of diagnosis and at relapse. Data were obtained from GSE18497 leukemia dataset. Sample size of the dataset is detailed in Supplementary Table 1. c CD1c expression in TCGA-AML and TCGA-Diffuse Large B Cell Lymphoma (DLBCL) tumor samples (T) compared to their corresponding normal tissues (N). The analysis included 173 AMLs and 70 normal bone marrow samples, and 47 DLBCLs and 337 normal blood samples (Table S2). Data on tumor samples were obtained from TCGA, while normal sample data were obtained from GTEx. CD1c expression was considered significant at *P < 1.00E−10 in a one-way ANOVA. In the box plots, the box is enclosed between the first quartile (25th percentile) and the third quartile (75th percentile), the center is represented by the median, the whiskers are defined by 1.5 times the interquartile range (i.e., it is the distance between the upper and lower quartiles).