Fig. 5: Protein glycosylation showed minimal sex differences in the brain compared to plasma in mice.
From: Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues
Comparison of the top 10 most abundant protein N-glycans in plasma (A), cortex (B), and cerebellum (C) reveals differences between sexes, with much greater divergence between male and female mice in the plasma than in either brain region. D Comparison of the 10 most abundant protein O-glycans in the cortex revealed minor variation between genders, though limited sample size prevented statistical analysis. For plasma samples, male = 8, female = 6. For brain N-glycans, male = 6, female = 4. For brain O-glycans, male = 3, female = 2. Corresponding glycan structures are shown above each assigned peak, with distinct isomers corresponding to the same mass shown in brackets. Data presented as mean +/− SEM for percent abundance of each peak, with unpaired two-tailed t-tests assuming unequal variance performed for sex comparisons of individual glycans. p values *<0.05, **<0.01, and ***<0.001. Source data are provided as a Source Data file.
