Table 2 Brain O-glycans.
From: Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues
Glycan Category | Cortex | Hippocampus | Striatum | Cerebellum | F-value | p-value |
|---|---|---|---|---|---|---|
O-GalNAc | 84.1 ± 0.3 | 77.7 ± 0.2 | 82.3 ± 0.9 | 73.5 ± 2.5 | 8.83 | 0.005 |
O-Man | 10.7 ± 0.4 | 18.9 ± 3 | 13.9 ± 1.1 | 25.0 ± 2.5 | 14.13 | 0.0009 |
Fucose | 9.9 ± 1.0 | 7.1 ± 0.3 | 7.0 ± 1.2 | 10.0 ± 1.2 | 1.41 | 0.3 |
NeuAc | 89.2 ± 0.9 | 89.7 ± 0.2 | 91.4 ± 1.2 | 86.6 ± 1.8 | 2.3 | 0.15 |
NeuGc | 1.28 ± 0.15 | 1.72 ± 0.02 | 2.09 ± 0.08 | 2.15 ± 0.15 | 9.56 | 0.004 |
O-GalNAc Core 1 | 90.0 ± 1.0 | 94.3 ± 0.1 | 94.1 ± 1.1 | 90.1 ± 1.2 | 4.22 | 0.04 |
O-GalNAc Core 2 | 10.0 ± 1.0 | 5.7 ± 0.1 | 5.9 ± 1.1 | 9.9 ± 1.2 | 4.22 | 0.04 |
O-GalNAc Fucose | 7.4 ± 1.0 | 3.8 ± 0.2 | 4.2 ± 1.1 | 6.7 ± 1.4 | 1.94 | 0.19 |
O-GalNAc NeuAc | 90.6 ± 0.9 | 94.2 ± 0.1 | 94.3 ± 1.2 | 89.9 ± 1.3 | 4.05 | 0.04 |
O-GalNAc NeuGc | 1.2 ± 0.2 | 1.0 ± 0.1 | 1.8 ± 0.2 | 2.1 ± 0.1 | 11.23 | 0.002 |
O-Man Core M1 | 77.2 ± 2.4 | 85.5 ± 1.4 | 74.0 ± 4.1 | 97.0 ± 0.6 | 14.9 | 0.0008 |
O-Man Core M2 | 22.8 ± 2.4 | 14.5 ± 1.4 | 26.0 ± 4.1 | 3.0 ± 0.6 | 14.9 | 0.0008 |
O-Man Fucose | 22.0 ± 1.1 | 20.3 ± 0.7 | 21.7 ± 1.9 | 19.5 ± 2.2 | 0.44 | 0.73 |
O-Man NeuAc | 78.2 ± 1.3 | 76.5 ± 0.5 | 77.1 ± 1.6 | 78.6 ± 2.5 | 0.24 | 0.87 |
O-Man NeuGc | 2.8 ± 0.6 | 5.0 ± 0.1 | 4.3 ± 0.5 | 2.3 ± 0.3 | 7.05 | 0.0098 |
