Fig. 3: Repertoire analyses and characterization of predominant antibody germlines. | Nature Communications

Fig. 3: Repertoire analyses and characterization of predominant antibody germlines.

From: B cell analyses after SARS-CoV-2 mRNA third vaccination reveals a hybrid immunity like antibody response

Fig. 3: Repertoire analyses and characterization of predominant antibody germlines.The alternative text for this image may have been generated using AI.

a Radar plot shows the distribution of IGHV;IGHJ germlines among the three different groups. SN2, SN3, and SP2 are shown in light blue, dark blue, and red, respectively. Heatmap represents the Log2 fold change (FC) among groups. b Network plot shows the clonally-expanded antibody families in SN2 and SN3. Centroids and nAbs from SN2 and SN3 groups are shown in gray, light blue, and dark blue, respectively. Clusters and expanded clones are highlighted in bright green and bright purple, respectively. c–f The graphs show the V gene somatic mutation frequency (left panel) and neutralization potency (IC100; right panel) of IGHV3-53;IGHJ6-1 (c), IGHV3-66;IGHJ4-1 (d), IGHV1-58;IGHJ3-1 (e), and IGHV1-69;IGHJ4-1 (f) gene derived nAbs, against the original SARS-CoV-2 virus first detected in Wuhan, China, and all SARS-CoV-2 VoCs. The number and percentage of nAbs analyzed are denoted on each graph. Source data are provided as a Source Data file.

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